This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9

Comments · 293

• JO

  @JosephMcGhee-i5n · 7 days ago

  I am an 82 year old engineer and have done testing of medical electronics. When I recently got the onset of edema in legs and feet, I was able to REVERSE the swelling in legs and feet and also the pains quickly by the application of low voltage pulses into the lymph pumps removing the lymph clogs and this has lasted weeks after the initial therapeutic application of the voltage pulses with a cheap TENS device.

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• MA

  @MarcosCapixaba · 9 days ago

  <b>*Glycine &amp; Longevity — Short Summary*</b> 🧬<br><br>- <b>*What it is:*</b> Glycine is the simplest amino acid, sweet-tasting, cheap, and found even in space. It&apos;s used to build collagen and glutathione (a key antioxidant). 🍬<br>- <b>*Why it matters:*</b> It may mimic methionine restriction by using up methyl groups, which downregulates mTOR and triggers maintenance/repair mode — similar to fasting or caloric restriction. ⚙<br>- <b>*Health benefits:*</b> Animal studies show lifespan extension (worms, flies, mice, rats — up to ~28–31% in rats). Human trials suggest improved glutathione, reduced inflammation, better blood sugar, lower blood pressure, and improved strength/metabolism. ❤<br>- <b>*Dosing:*</b> David takes ~2 g/day; studies use up to 7–10 g. Start low, consult a doctor, and don&apos;t overdo it. ⚠<br>- <b>*TMG vs. glycine:*</b> TMG (betaine) helps strength and skin but may counteract glycine&apos;s methionine-depleting effect — don&apos;t take both together. 🚫<br>- <b>*Takeaway:*</b> Glycine is one of the safest and most promising longevity molecules, but it&apos;s not a substitute for exercise, good diet, and sleep. 🏃‍♂🥗😴

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• JE

  @jeffhogueison1656 · 9 days ago

  3 grams of glycine a day is a good sweet spot on the average for general use. Enough to do good but not too much to harm you.

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• MI

  @MikeMcDaniels-w1u · 4 days ago

  My pal is on metformin for 25 years. He is 90 years old, still can see, still can drive. So his sugar has been controlled, thus has a better life.

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• PE

  @PerAsperaAdAstra8755 · 10 days ago

  Dr. Sinclair notes that human trials using GlyNAC (a combination of <b>Glycine and N-Acetylcysteine*) showed reversals in several hallmarks of *aging</b> within 16 weeks, including improved mitochondrial function, reduced inflammation, reduced insulin resistance, and enhanced physical strength [<a href="https://www.youtube.com/watch?v=oUcmsV25usI&amp;t=1944">32:24</a>].

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• HE

  @helgabruin2261 · 10 days ago

  My concern for glycine is it&apos;s potential to feed rapidly dividing cancer cells. &nbsp;I&apos;ve beat 3 cancers, so I have great concerns of glycine supplementation.

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• CA

  @camiloandresleguizamon3624 · 10 days ago

  Many thanks, David, for improving our lives

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• HY

  @Hypnotic6 · 9 days ago

  Well, this is the next frontier in this game called - don&apos;t die ( thank you prof. David Sinclair your are the best ) :)

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• AC

  @ACZ-g2c · 5 days ago

  Riddle me this one:<br><br>Checked GlyNAC funding sources<br>Yes — there&apos;s a clear corporate link. The key researcher is Dr. Rajagopal Sekhar at Baylor College of Medicine (the USC connection comes through co-inventors on the patent, Stephen Kirnon and Eric Freedland).<br>The Nestlé connection:<br>Baylor College of Medicine holds a patent on GlyNAC (US Patent 10,952,982, filed 2016, granted 2021). <br>That patent was licensed to Nestlé Health Science, which markets GlyNAC in the US as Celltrient™ Cellular Protect. <br>So Nestlé has a direct commercial stake in the IP that the research produced.

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• KA

  @karinsingh1750 · 10 days ago

  Many thanks as always Dr David 🙏

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• SA

  @samuelholmes1228 · 9 days ago

  Thank you David for sharing your research. You are an awesome human being.

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• DA

  @daveoatway6126 · 10 days ago

  I&apos;ve enjoyed following Dr. Sinclair for many years. I started (and continue) taking 2 gm of NMN every day. I have been adding glycine to my coffee with powdered MCT 8, and at night before bed. Thank you, Dr. Sinclair! I am 82 and walk 3-5 miles most days in the sun. I do take any prescription medications.

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