The Longevity Revolution Is Here | Lifespan with Dr. David Sinclair - S2, Ep. 1

Comments · 318

• BR

  @brooksthornhill8056 · 3 months ago

  I started following Dr. Sinclair when I was 38. I’m 35 now.

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• PR

  @premsatya2 · 11 days ago

  What stands out in this episode is how clearly you translate a frontier of science into something people can actually understand and act on. You don’t hype longevity — you ground it. You show that aging isn’t just wear and tear but a loss of biological information, and you make that idea feel both intuitive and empowering. The examples you choose — from super‑centenarians to elite performance at 80 to epigenetic reprogramming entering human trials — turn possibility into something concrete. You’re not just reporting breakthroughs; you’re giving people literacy in a future that’s already unfolding. That clarity is rare, and it’s exactly what makes your work valuable.     😀

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• CR

  @creightonfreeman8059 · 3 months ago

  In 2019 when the information in "Lifespan" came out I kept telling my parents, who both had macular degeneration, "just stay healthy a few more years; a gene therapy to repair your vision is coming in two or three years". Unfortunately, my father died from cancer/cancer treatment complications in 2023, and my mother fell and broke her hip the following year and passed away suddenly about a month after coming home from the hip replacement surgery. I was so angry that Covid-19 and FDA regulations had slowed down the adoption of cellular reprogramming into clinical practice, and so sad that neither of my parents got to benefit from it.

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• LU

  @luzbuensuceso2916 · 2 months ago

  Lifespan has become my university and Dr. David Sinclair, my professor. Not a day has gone without me listening to one of this podcasts. ❤

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• FU

  @furkansimsek33 · 3 months ago

  <a href="https://www.youtube.com/watch?v=YRGejckRNpQ">00:00</a> Introduction to the Longevity Revolution and Season Two Overview<br><a href="https://www.youtube.com/watch?v=YRGejckRNpQ&amp;t=459">07:39</a> Extraordinary Feats of Human Longevity and Performance<br><a href="https://www.youtube.com/watch?v=YRGejckRNpQ&amp;t=1235">20:35</a> The Information Theory of Aging and Epigenetic Information<br><a href="https://www.youtube.com/watch?v=YRGejckRNpQ&amp;t=1780">29:40</a> Discovering Longevity Genes and Sirtuins in Yeast<br><a href="https://www.youtube.com/watch?v=YRGejckRNpQ&amp;t=2307">38:27</a> Testing Epigenetic Changes via the ICE Mouse Model<br><a href="https://www.youtube.com/watch?v=YRGejckRNpQ&amp;t=3028">50:28</a> Reversing Aging and Regrowing Nerves Using OSK Factors<br><a href="https://www.youtube.com/watch?v=YRGejckRNpQ&amp;t=3537">58:57</a> ER100 Human Clinical Trials and Episode Summary

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• DA

  @dannoringer · 3 months ago

  I&apos;m counting the days until when skin, hair, organs, and more can be renewed. &nbsp;Keep up the good work Dr. Sinclair and associates.

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• RI

  @RichardDouglasGali · 3 months ago

  Thank you for everything Mr.Sinclair

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• GO

  @goodphone156 · 3 months ago

  Thank you David for your contribution in this field!

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• EL

  @Eloibaby · 3 months ago

  Ahahja &quot;remember, life&apos;s short... So let&apos;s change that together&quot;....😅

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• DI

  @diegoescorpion · 3 months ago

  Interesting case. There is a man named Carlos Alberto Lindao Vera, known as “Don Carlos,” from Ecuador, who reportedly maintains an active lifestyle.<br><br>He is said to retain an excellent memory and continues to follow a physically demanding daily routine. Each morning, he travels through the mangrove estuaries by canoe and works in the traditional production of charcoal.<br><br>Don Carlos believes that staying physically active helps preserve health and vitality. He also credits his well-being to a diet based on fresh seafood, rice, avocado, and green plantains, while avoiding processed foods.<br><br>Whether or not every detail can be verified, his story offers an interesting perspective on resilience, physical activity, and healthy life.

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• V1

  @v1sh22 · 3 months ago

  Dr Sinclair and team — thank you for such a digestible presentation on where the science currently stands. Your work is genuinely exciting, and getting the FDA on side is a real achievement. I particularly enjoyed the simplified models used to give visual representation to more complex concepts; they made the whole thing wonderfully accessible to the layman. A big congratulations too to your father for having the discipline to put in the work and maintain his health — a living testament to the cause. I await your next video with great anticipation!

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• PA

  @patchareecherdchukiet3110 · 3 months ago

  Thank you for coming back giving us a new season.

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