25 Million Stem Cells vs PRASAD™ | What Are You Actually Getting for Your Knee?
1.1K views · Sep 18, 2026 · Science & Technology
Comments · 1
@MadrasJointRejuvenation · 12 days ago · pinned
Key Clinical References & Study Data Mentioned in This Video:<br>To help patients and colleagues examine the evidence directly, here are the primary peer-reviewed citations discussed:<br>1. Phase 3 Trial Data for Allogeneic Cultured Stem Cells (Stempeucel-OA / CiploStem / StemOne):<br>12-Month Outcomes: Gupta et al. (2023). Efficacy and Safety of Cultured Allogeneic Mesenchymal Stromal Cells in Knee Osteoarthritis: A Randomized Controlled Phase 3 Trial. The American Journal of Sports Medicine, 51(9), 2254–2266.<br>24-Month MRI Cartilage & Durability Data: Published in Osteoarthritis and Cartilage Open (evaluating pain, function, WOMAC scores, uCTX-II cartilage biomarker degradation, and MRI T2-mapping showing medial compartment cartilage preservation vs progressive placebo worsening).<br>2. Intra-Articular vs. Subchondral Delivery (15-Year Follow-up):<br>Prof. Philippe Hernigou et al. (2021): "Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study." International Orthopaedics, 45(5), 1285–1299. (Demonstrating that target location matters: 20% conversion to joint replacement with subchondral delivery vs. 70% with intra-articular injection at 15 years in bilateral knees).<br>(Note: Have you been recommended the 25 million stem cell injection, or are you currently exploring joint preservation options? Share your questions or experience below—I read every comment.)
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