脂肪の正体｜減った脂肪の84%は、吐く息で出ていく

When you lose weight, where does the lost fat go? Of 10 kilograms of fat, 8.4 kilograms are exhaled as carbon dioxide through your lungs. The remaining 1.6 kilograms become water. This video delves into topics ranging from the molecular structure of fat, the cells that store fat, why the number of fat cells remains relatively constant in adults, the hormone leptin released by fat cells, the mechanism by which fat is broken down into carbon dioxide and water, why weight loss doesn't always follow calculations, brown fat which generates heat, and why humans are naturally fatty animals—all at a university lecture level. ▼ Table of Contents (Chapters) 0:00 Opening 0:58 Chapter 1: The Fat Molecule 2:58 Chapter 2: Why Does the Body Store Fat? 4:58 Chapter 3: Cells That Store Fat 6:52 Chapter 4: The Number of Fat Cells Doesn't Change 9:22 Chapter 5: Fat Sends Signals 12:48 Chapter 6: Leptin Doesn't Make You Lose Weight 15:36 Chapter 7: How Fat Burns 18:21 Chapter 8: Where Does Lost Fat Go? 21:55 Chapter 9: It Doesn't Lose Fat as Calculated 24:52 Chapter 10: Fat That Generates Heat and Fatty Animals 29:25 Conclusion ▼ What you'll learn from this video: The structure of body fat (triglycerides) and why fat contains 9 kilocalories per gram The number of fat cells in adults remains relatively constant, with approximately 10% being replaced annually (a study using carbon-14 from nuclear tests) Fat cells communicate fat levels to the brain via leptin, and why many people didn't lose weight with leptin injections Approximately 84% of lost fat is exhaled, and why weight loss doesn't always follow a simple "subtraction" process Brown fat, present in adults, and its effects are still under debate This video explains the body's mechanisms. It does not recommend weight loss or fasting. ▼ Sources (main ones) ・Meerman R, Brown AJ. When somebody loses weight, where does the fat go? BMJ 2014;349:g7257 (UNSW Newsroom December 17, 2014) ・FAO. Food energy – methods of analysis and conversion factors. 2003 ・King RFGJ, Jones B, O'Hara JP. Eur J Appl Physiol 2018;118:283 ・Lass A, Zimmermann R, Oberer M, Zechner R. Prog Lipid Res 2011;50:14 ・Nishimoto Y, Tamori Y. J Atheroscler Thromb 2017;24:989 ・Spalding KL et al. Dynamics of fat cell turnover in humans. Nature 2008;453:783 ・Leading the charge in leptin research: an interview with Jeffrey Friedman. Dis Model Mech 2012 ・Zhang Y et al. Nature 1994;372:425 / Halaas JL et al. Science 1995;269:543 ・Montague CT et al. Nature 1997;387:903 ・Considine RV et al. N Engl J Med 1996;334:292 ・Heymsfield SB et al. JAMA 1999;282:1568 ・Oral EA et al. N Engl J Med 2002;346:570 ・Wanders RJA et al. J Inherit Metab Dis 2010;33:479 ・Hall KD. Int J Obes 2008;32:573 / Hall KD et al. Lancet 2011;378:826 ・Cannon B, Nedergaard J. Physiol Rev 2004;84:277 ・Cypess AM et al. / van Marken Lichtenbelt WD et al. / Virtanen KA et al. N Engl J Med 2009;360 ・Saito M et al. Diabetes 2009;58:1526 ・Human brown fat and metabolic disease: a heated debate. J Clin Invest 2023 ・Cunnane SC, Crawford MA. Comp Biochem Physiol A 2003;136:17 ・Stewart WK, Fleming LW. Postgrad Med J 1973;49:203 ▼Credit Music: 'Origami' by Scott Buckley – released under CC-BY 4.0. www.scottbuckley.com.au ― A university for adults who want to learn ― This channel delves into all kinds of topics, exploring them to the deepest levels and cutting edge of their respective fields. ▶ Share what you've learned in the comments. Questions and opinions are welcome; we'll answer each one. ▶ Subscribe to the channel and join us on our next exploration. #fat #thescienceofdiet #adultlearning