What Really Happens After 3 Years on GLP-1s & 150+ lbs Lost.

What really happens after three years on GLP-1 medications? Christopher and Laraine Durham have been taking tirzepatide for three years. Together, they have lost more than 150 pounds using GLP-1 treatment, including Mounjaro, Zepbound and compounded tirzepatide. Now they’re looking back at where they started, what surprised them, what was harder than expected and what life on GLP-1s actually looks like three years later. They talk openly about food noise, side effects, constipation, cost and insurance, compounded versus brand-name tirzepatide, weight-loss expectations, obesity stigma and what it feels like to live in a much smaller body after decades of struggling with weight. They also get into the part of the GLP-1 journey that doesn’t get nearly as much attention: maintenance. Christopher has maintained a loss of more than 100 pounds, while Laraine has maintained a loss of more than 50 pounds. They explain why they continue taking their medication, how their thinking about obesity has changed and why reaching a goal weight wasn’t the end of treatment. Three years ago, they weren’t sure tirzepatide would even work. Today, they’re still taking their weekly shots, still maintaining their weight and still learning what long-term treatment of obesity looks like in real life. This is their three-year GLP-1 story: the weight loss, the side effects, the money, the maintenance, the unexpected changes and the question so many people ask: was it worth it? The Downsized shares the real-life experiences of GLP-1 patients along with news, research and conversations about medications including Mounjaro, Zepbound, Ozempic, Wegovy, compounded tirzepatide, compounded semaglutide and emerging treatments such as Foundayo. Christopher and Laraine are patients, not medical professionals. Their experiences are their own and are not medical advice. Always discuss medications, dosing, side effects and treatment decisions with a qualified healthcare professional. +++++++++++++++++++++++++++++++++++++++ Start your weight loss journey today! We use Mochi Health: https://app.joinmochi.com/eligibility... Use Laraine’s code for $40 off: QIYGO8. Get your Hume BodyPod today and use our exclusive Downsized code for up to 20% total savings! 👉 Use our Code: https://humehealth.com//discount/THED... Get your Hume Band 2.0 Use our link: Code: THEDOWNSIZED20 UTM link: https://humehealth.com//discount/THED... SHOP OUR AMAZON STORE: https://a.co/d/0gGe1MYq BOOK THE DOWNSIZED AT SEA CRUISE 2027: https://thedownsized.org/downsized-at... GET YOUR DOWNSIZED LIVE! ON TOUR TICKETS: https://thedownsized.org/meet-ups/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: @thedownsized FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ +++++++++++++++++++++++++++++++++++++++ 00:00 Three Year Tirziversary 00:36 First Shots Together 01:26 Ozempic Sticker Shock 03:48 Elaine Inspired Leap 06:57 Compounding? 08:03 Early Results and Food Noise 09:45 Before and After Numbers 12:26 Marker 13:25 Going Public on YouTube 15:49 Oprah Validation Moment 20:47 Shortages and Pharmacy Stigma 23:53 Branded vs Compounded 28:31 Maintenance Doses and Mindset 31:18 Obesity as a Disease 31:57 Hardest Part of the Journey 33:05 Paying For GLP-1s 36:14 Side Effects Reality Check 39:08 Unexpected Health Perks 41:50 Living In A Smaller Body 47:22 Maintenance Mindset 51:25 Staying On Track Daily 54:51 Best Resources To Learn 59:22 Regrets And Hope 01:00:46 One Tip Get Started 01:02:02 What’s Next For The Channel 01:03:31 Mochi Health How To 01:04:19 Three Year Thank You