Ads skipped

100+ Isaac Facts You DON'T Know

282K views · Dec 21, 2025 · Gaming

Comments · 507

  • @loonwar5231 · 9 months ago

    Now cut this up into 100+ Isaac shorts you probably never seen before and watch the money printer go brrrr.

    979

  • @kirbothepopopo · 9 months ago

    Actually my mom is edmen mcmillion so I knew all of these

    1.4K

  • @Bananaman559 · 9 months ago

    No Matt i didn't know The Binding Of Isaac Rebirth

    662

  • @equinox_801 · 9 months ago

    For the mirror bombing case, I once survived. As soon as I realized what I accidentally did, I instantly started sharp plugging the red key to get an error room. I lost most of my dead cat lives, but survived.

    158

  • @stevenharvey8831 · 9 months ago

    Bonus Big Horn fact! Big Horn has a a low percentage chance to attack by holding up up little Horn who will shoot three small black balls at Isaac. If Big Horn is killed during this attack he will drop Little Horn to continue the fight for him.

    56

  • @boboisnotyou · 9 months ago (edited)

    A bunch of additional info on some of the facts:<br>-Eternal hearts shielding you while in ghost form only works if Isaac has exposed red hearts, having soul hearts will not make the eternal heart take the hit for you<br>-Big Horn takes additional damage while stunned with a bomb<br>-2-segmented Chub cannot spawn chargers as she does not have an ass

    121

  • @alestory656 · 9 months ago

    I learned the fly evolution one just because I autismed and read the wiki of monsters, not even once have I found that in a normal run

    297

  • @tuttoki · 9 months ago

    <a href="https://www.youtube.com/watch?v=WaucQQroChg&amp;t=660">11:00</a> bro threw a fun fact 😭🥀

    70

  • @Homerak · 9 months ago

    I have one!<br>The beast fight has 2 invisible ladders on far left and far right that you never use since you have flight but can be used by stuff like a Meat Boy familiar.

    163

  • @mariosonicfan2010 · 9 months ago

    fun fact 41.5: this interaction is actually based on a bug present in earlier versions of the game, where if you were suplexing something right as berserk wore off, the thing you&apos;re suplexing would just get deleted. instead of just removing the bug, they turned it into an intentional interaction.

    49

  • @stormRed · 9 months ago

    This game is like a fractal of content, you could talk about it for a million years honestly

    15

  • @Strongman8000 · 9 months ago

    <a href="https://www.youtube.com/watch?v=WaucQQroChg&amp;t=757">12:37</a> hit it with your what?

    219

Up next

LIVE

50+ Things You NEED TO KNOW from this Isaac Patch

Another Matt Playing Isaac · 116K views

LIVE

Isaac CHARACTERS Tips & Tricks

Another Matt Playing Isaac · 501K views

LIVE

Your Isaac Challenges are HORRIBLE..

Another Matt Playing Isaac · 186K views

LIVE

Horrors on the Internet Archive

Farrell McGuire · 4.3M views

LIVE

Rerolling Destiny [Binding Of Isaac Repentence]

Reldrik Goes Rogue · 86 views

LIVE

The (Somewhat) Complete Lore of Silksong

mossbag · 2.6M views

LIVE

16 Pokémon with Useless Moves

MandJTV · 838K views

LIVE

Ranking Isaac BOSS Items by Their USEFULNESS

Another Matt Playing Isaac · 97K views

LIVE

A Speedrun About Unclogging Drains

EazySpeezy · 1M views

LIVE

Ranking Isaac CHALLENGES By Their UNLOCKS

Another Matt Playing Isaac · 750K views

LIVE

Beating Isaac's UNWINNABLE Seeds

Another Matt Playing Isaac · 973K views

LIVE

Can You Erase EVERY Isaac Enemy in a SINGLE Run?

Another Matt Playing Isaac · 303K views

LIVE

Ranking Isaac Characters BY THEIR UNLOCKS

Another Matt Playing Isaac · 1.6M views

LIVE

If You Agree with Me, I RESET

Another Matt Playing Isaac · 74K views

LIVE

A Nuzlocke with 250,000+ Pokémon

Jacob Alpharad · 1.5M views

LIVE

Can YOUR Synergy Idea Beat Isaac Under 5 Seconds?

Kayhos · 128K views

LIVE

Isaac TRANSFORMATIONS Ranked By Their IMPACT

Another Matt Playing Isaac · 300K views

LIVE

Why Tainted Cain is S+ TIER

Another Matt Playing Isaac · 288K views

LIVE

I forced my chat to use TBOI's most HATED item...

Quinnjamin · 10K views

LIVE

EVERY Tainted Lost Mark but if I Get Hit, I BAN a Viewer... I lost everyone.

Another Matt Playing Isaac · 231K views

YouTube, with the door locked.

Aegis plays a clean stream instead of YouTube's player, so pre-roll ads, trackers, and fingerprinting never ride along. Drop Shields any time if you want the official player back.