Making and Testing The ANTI-SPICY Molecule (Capsazepine)

Comments · 412

• CH

  @Chemiolis · 2 years ago · pinned

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• AN

  @andrewamann2821 · 2 years ago

  So... &nbsp;It prevents the burn going in... &nbsp;But that&apos;s only half the battle, sir.

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• SK

  @skeptical_thinkers · 2 years ago

  I was wondering when someone would finally get around to this synthesis! I actually managed to get a hold of some Capsazepine a couple years ago and my experience was similar. For me it reduced the spicyness, but only for about a half an hour, and didn&apos;t reduce it any more than perhaps drinking a glass of milk.

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• HA

  @hammerth1421 · 2 years ago (edited)

  That&apos;s an impressive multi-step synthesis for &quot;amateur&quot; chemistry!<br><br>It also serves as a neat demonstration of the &quot;general synthesis loop&quot; of organic chemistry: dissolve in solvent -&gt; reaction -&gt; workup -&gt; distill off the solvent -&gt; repeat

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• PA

  @pauljames5826 · 2 years ago

  I was surprised at an Indian restaurant where they served no alcohol but did have mango nectar as an aperitif/beverage. &nbsp;While eating some of the mixed crisps only one item in the mix was SPICY — I grabbed my mango nectar and took a drink — to my surprise, the heat was stopped. &nbsp;I’m thinking that papain might have been the actor in this pleasant discovery(?)

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• LR

  @lrvfb · 2 years ago

  Man, you didnt really just eat a chemical in a long multi-step synthesis without even doing a column after the last step?!?😂😂

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• ER

  @erokfussell · 2 years ago

  Pack your column by running several column lengths of solvent prior to adding sand. Tighter packed columns give better separation as well!

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• NA

  @nathanieljames7462 · 2 years ago

  Non-chemists when he says he washed it with water: &nbsp;The f*ck you did.

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• TH

  @thomasrussell4674 · 2 years ago

  Theres another anti spicy compound.<br><br>Your capsazepine just blocks heat, but there&apos;s another one that functionally reverses the action of the trpv1 receptor, it&apos;s called<br><br>&quot;Iodoresiniferatoxin&quot;.<br><br>If you consume it, it makes you feel cold. <br><br>Im guessing here i could be wrong but i believe menthol is different, and works on a cold sensing receptor, but iodoresiniferatoxin actually latches onto a generally heat sensing receptor with an action functionally the opposite of capsaicin.<br><br>I hope you enjoy reading about it!<br><br>You might be able to tell me, is iodoresiniferatoxin just copying menthol and they all just work on the same receptor, &nbsp;<b>OR</b> if it really is different and iodoresiniferatoxin is unique, pretty much in the same league as capsazepine with your one in this vid blocking the receptor, and iodoresiniferatoxin acting as an antagonist at the same receptor.<br><br>Great video btw, thanks!

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• NA

  @nathanieljames7462 · 2 years ago

  Eating my favourite combination of spicy compounds as I watch this.<br>Just feels proper.

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• CH

  @chemdelic · 2 years ago

  I can’t begin to imagine the work you put in on this. Great job brother!

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• MD

  @mduvigneaud · 2 years ago

  I love this video! :D Personally I like the pain from eating spicy food. Y&apos;know, the huge endorphin rush from the pain. lol

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