Testosterone use in Prostate Cancer

Comments · 5

• JA

  @janetw9430 · 2 years ago

  As a man get older, testosterone goes down and cancer risks goes up.

• TE

  @TERRY-cb2ku · 2 years ago

  Quality of life or quantity of life,  that's the greatest question I suppose. Especially for men already in their seventies and eighties. I'm somewhat on the fence about it. This needs much further study. I've just started this journey and am waiting for a diagnosis. Pray for me.

  1

• GL

  @glenbearh9109 · 3 years ago

  PCA two years since SBRT PSA has dropped from 2.74 to 1.06 yet no urologist wants to prescribe testosterone. I am severely hypogonadal at level 25 due to years of opiate use. This makes my quality of life horrible with depression and anxiety. I could not stand it anymore so I went to a clinic and fudged my history and have been on TRT throughout treatment for cancer. Problem is I want to be upfront about it and also it costs a lot of money to go to the clinic. Help! Any doctor in NY?

  1

• RO

  @roberthuff3122 · 1 year ago

  🎯 Key points for quick navigation:<br><br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c">00:00</a> 📜<b> Overview of Testosterone in Prostate Cancer</b><br>- Introduction to the historical perspective of testosterone&apos;s role in prostate cancer.<br>- Discussion about Dr. Huggins&apos; research from the 1960s, establishing the belief that testosterone fuels prostate cancer.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=138">02:18</a> 🔍<b> Re-evaluating Testosterone&apos;s Impact</b><br>- Analysis of meta-analyses and studies investigating testosterone levels and the risk of developing prostate cancer.<br>- Presentation of the saturation model, proposing a nuanced relationship between testosterone and prostate cancer.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=425">07:05</a> ⚖<b>️ Clinical Implications of Hypogonadism</b><br>- Discussion on the prevalence of hypogonadism in the aging male population and its coexistence with prostate cancer.<br>- Examination of testosterone replacement therapy (TRT) in men with hypogonadism and low-grade prostate cancer.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=791">13:11</a> 🧠<b> Considerations for Active Surveillance</b><br>- Review of studies on hypogonadal men on active surveillance and the impact of TRT on disease progression.<br>- Insight into imaging techniques like MRI to monitor prostate cancer progression.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1123">18:43</a> 🌟<b> Quality of Life and TRT</b><br>- Importance of TRT in improving quality of life and various health indicators in prostate cancer patients.<br>- Survey results on Canadian urologists&apos; practices regarding TRT and active surveillance.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1460">24:20</a> ⚙<b>️ Post-Treatment TRT Safety</b><br>- Safety of TRT post-radical prostatectomy or radiation treatment in men with undetectable PSA levels.<br>- Large database analysis and smaller studies showing TRT does not increase the risk of biochemical recurrence or mortality.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1323">22:03</a> 📜<b> TRT Guidelines Post-Prostate Cancer Treatment</b><br>- AUA and EAU guidelines permit TRT one year post-radical prostatectomy given no residual disease,<br>- COA offers no specific time but suggests TRT in the absence of active disease,<br>- Rising PSA levels can complicate decisions about TRT during intermittent ADT.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1449">24:09</a> 📈<b> Intermittent ADT and Hypogonadism</b><br>- ADT duration affects risk of becoming permanently hypogonadal,<br>- Intermittent ADT patients are discussed in the context of TRT resumption,<br>- Detection of hypogonadal men increases with prolonged ADT.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1569">26:09</a> 🧪<b> Limited Data on TRT in Metastatic Prostate Cancer</b><br>- Study of 7 men with advanced prostate cancer on TRT shows no rapid disease progression,<br>- Outcomes of TRT in metastatic cases remain unclear with limited follow-up,<br>- TRT impacts on disease flare or vertebral compromise were minimal in study.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1653">27:33</a> 🔄<b> Bipolar Androgen Therapy (BAT)</b><br>- Emerging concept with potential therapeutic uses for prostate cancer,<br>- 14 men with castration-resistant prostate cancer showed PSA decline with BAT,<br>- BAT cycles high testosterone doses with ADT to possibly resensitize cancer cells.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1793">29:53</a> 🚀<b> Phase Two Trials with BAT</b><br>- High testosterone cycles improve quality of life compared to continuous ADT,<br>- Results show improved PSA and radiographic outcomes,<br>- Rapid fluctuations in testosterone might cause significant variations in patient experience.<br><a href="https://www.youtube.com/watch?v=FRPA3igMX7c&amp;t=1931">32:11</a> 🔬<b> BAT in Metastatic Castration-Resistant Prostate Cancer</b><br>- Phase two trial showed PSA reductions even after progression on enzolutamide,<br>- Enzalutamide re-challenge had efficacy post-BAT therapy,<br>- BAT may re-sensitize cancer cells, improving the response to previous treatments.<br><br>Made with HARPA AI

• JE

  @jean-francoiscote3914 · 1 year ago

  400 mg every 7 days is way too much . But every 4 weeks is not very good for mood wise