Pros & cons of GLP-1 weight loss drugs | Dr. Ralph DeFronzo

Comments · 261

• PL

  @plasticface333 · 1 year ago

  GLP drugs are awesome, i train hard and hit protein target, ive kept most of the muscle

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• BA

  @BarryFranks · 1 year ago

  On tirzepatide. It works. Food drive significantly decreased. I’m taking creatine, whey and ingesting daily protein targets while doing resistance training. I have had very little GI trouble, with the only exception being one evening my heartburn was pretty severe, but even that I can attribute a lot to dietary choices I made. If you’re like me and your whole universe would center in on food, with very little ability to moderate that drive, then a GLP-1 might be the single best option for you.

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• EC

  @eckankar7756 · 1 year ago

  I wish Peter would control his ADD and let the guest finish a sentence.

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• JA

  @jasminecrandall2262 · 1 year ago

  It obviously depends on how overweight you are. Sarcopenia is the least of your worries when you have hypertension, hyperglycemia and hyperlipidemia.<br>The trick would be to do regular weight resistance while reducing body weight.

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• JE

  @jermboat44 · 1 year ago (edited)

  Absolutely fascinating discussion. It&apos;s also been interesting watching expert consensus on glp-1s increasingly shift away from cautious optimism to forward looking potential.

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• CO

  @compoundhq1 · 5 months ago

  the part about muscle loss being the real hidden cost of GLP-1s hit me hard - my husband&apos;s been on tirzepatide and we&apos;ve been so focused on the scale we forgot to protect his muscle, adding resistance training this week for sure

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• JO

  @JoeKetterling · 1 year ago

  To be fair, the 6-minute walk test is a submaximal exercise test with ample validity and reliability in older populations and populations with special needs. IMO, it&apos;s more of a functional independence test than an aerobic capacity test. You can use it to estimate maximal oxygen uptake through a population-specific linear regression formula using distance covered, heart rate, age, height, weight, and sex as variables. However, as Peter alluded, it doesn&apos;t identify submaximal thresholds. Also, I imagine it lacks the sensitivity to detect meaningful differences in subject testing for individuals going through obesity treatment. Ultimately, a graded exercise test would be needed to identify the submaximal threshold, but these require much more setup than the 6-minute walk test. Thus, we need more exercise professionals in medicine. <a href="https://www.youtube.com/hashtag/thatsmytedtalk">#ThatsMyTEDTalk</a>

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• JO

  @Joseph_Christopher · 9 months ago

  The muscle loss concern illustrates why choosing the correct GLP peptide is critical. Single pathway peptides such as Semaglutide (Ozempic) work by quieting food, signaling and slowing the gastric process. It’s only mechanism for losing weight is inducing caloric deficit because, it simply makes you feel like crap when you eat. This will certainly cause you to lose weight, but as soon as you go off the medication, that weight likely will return. Dual and triple pathway GLP’s like &nbsp;Tirzepatide and Retatrutide also work on this gastric pathway, but add the benefits of insulin sensitivity, modulation, which directly confronts the root cause of the weight gain in the first place, which is insulin resistance. In the case of Retatrutide, which adds a third glucagon pathway, once your body is using insulin correctly, your muscles then are free to use the glucose for muscle work, thereby reducing muscle wasting. The key to all of this is eating protein and fat dense foods, but in moderate amounts to encourage, continued caloric deficit or equilibrium, coupled with intense resistance training to not only arrest muscle loss, but promote muscle growth while on a GLP. I explained these concepts in detail on my YouTube channel.

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• SA

  @sarahlawry7825 · 1 year ago (edited)

  Fat people&apos;s muscles look like wagyu beef, marbled with fat. So, of course, as you lose weight, it looks like muscle is reducing, but it&apos;s fat coming out the muscle too. Also, consider the side effects of obesity. GLPS needs to be paired with weight lifting and prioritize protein

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• BA

  @batboum · 1 year ago

  Under GLP1, there is a loss of &quot;gross&quot; lean mass, but for the remaining muscle mass, intramuscular insulin sensitivity improves their functioning, and improves the entire metabolic chain. It&apos;s subtle...

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• CH

  @Chuckthehandymansman · 1 year ago

  Muscle mass has always been an issue with losing weight folks take protein and creatine

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• SU

  @susanthomas5167 · 1 year ago

  Let your guest speak!

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