Hyperkalzämie: Notfall oder Nebenbefund? | AMBOSS-Podcast | 154

Not every case of hypercalcemia is a medical emergency – but when is urgent action required? In this episode, nephrologist Dr. Ingo Krenz explains which physiological mechanisms control calcium homeostasis, when hypercalcemia becomes dangerous, and what therapeutic options are available. From endocrine causes to malignant diseases, we examine the most important differential diagnoses and analyze practical case studies – a compact guide for precise diagnostics and targeted therapy in everyday clinical practice. Table of Contents: 00:22 Intro 02:07 The Basics: Definition, Function, and Albumin Correction 04:19 Physiology of Calcium Regulation 08:07 Excursion: Vitamin D 10:05 Electrolyte Imbalance Calcium: When Does It Become Dangerous? 13:07 Differential diagnoses by frequency 14:45 Differential diagnoses for elevated parathyroid hormone 18:05 Differential diagnoses for low parathyroid hormone 24:01 Hypercalcemia in hyperthyroidism 25:01 Milk-alkali syndrome 28:34 Symptoms of hypercalcemia 33:05 Treatment in an emergency situation 36:08 Interim conclusion 38:25 Case study 1: Indication for parathyroid surgery 43:56 Case study 2: Multiple myeloma 48:00 Case study 3: Iatrogenic hypercalcemia 52:33 Closing remarks *For the AMBOSS practice license:* https://go.amboss.com/podcast-praxisl... *More information on electrolyte imbalances and calcium in AMBOSS:* https://go.amboss.com/zp4 *For the Podcast episode "Kidney Diseases: From the U-Stix to Diagnosis":* https://go.amboss.com/t2l *For the podcast "Medical Think Tank":* https://go.amboss.com/sn7 *More about the AMBOSS podcast:* https://go.amboss.com/amboss-app *Disclaimer:* The content of the AMBOSS podcast is purely academic. It is intended for informational, educational, and training purposes only and is intended for medical personnel, medical students, and other healthcare professionals. The content is not suitable for treating real cases and is not a substitute for a visit to the doctor. The podcast is created with the greatest possible care. However, AMBOSS SE assumes no liability for the accuracy, completeness, or timeliness of the content. Statements made by interviewees are the sole responsibility of the interviewees themselves; they do not reflect our point of view. We select our interviewees solely based on their scientific expertise. We will specifically indicate any known business connections our guests may have with supporters of our podcast. Keywords Calcium, calcium, electrolytes, vitamin D, parathyroid hormone, hyperparathyroidism, parathyroid gland, hyperthyroidism, multiple myeloma, laboratory values, nephrology