How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich

Comments · 394

• RI

  @riffcrescendo1740 · 5 years ago

  Who knew that Chuck Norris was such a medical expert!!

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• EK

  @ekondigg6751 · 5 years ago

  At <a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=2340">39:00</a> We hear about apoptosis being inhibited. That, and serious damage to the mitochondria sounds to me like a recipe for cancer if we take Dr Seyfried&apos;s hypothesis that cancer actually begins with damaged mitochondria seriously.

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• GO

  @GodfreyMann · 5 years ago (edited)

  <a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=326">5:26</a> - (1) WHAT IS LINOLEIC ACID? (AKA LA)<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=411">6:51</a> - It’s a plant fatty acid not produced in animals [but animals can accumulate it].<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=468">7:48</a> - High consumption started with cottonseed oil in the USA (C18th).<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=475">7:55</a> - Cottonseed is highly toxic due to gossypol [a plant fatty acid].<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=488">8:08</a> - Removal of gossypol in C19th led to the launch of Crisco in 1911.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=529">8:49</a> - Scientists today use a blend of lard with seed oils to induce obesity and metabolic dysfunction in animals.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=570">9:30</a> - Evolutionary inconsistency in linoleic acid (LA) consumption in the last 100-200 years.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=580">9:40</a> - Ancestral whole-foods animal-based diet is low in LA.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=600">10:00</a> - c.f. Paul’s iInterview with Dr Chris Knobbe for LA history.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=612">10:12</a> - LA = 18-carbon, omega-6 fatty acid, two double bonds @ 9 &amp; 12 positions.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=650">10:50</a> - HYPOTHESIS = LA has driven chronic disease in the last 150-200 years.<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=679">11:19</a> - (2) HOW DOES LINOLEIC ACID CAUSE DISEASE?<br><br>(2a) - Metabolites of Linoleic acid cause disease:<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=699">11:39</a> - The problem is the double bonds in Polyunsaturated Fatty Acids (PUFAs) in both omega-6 and omega-3 fats.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=718">11:58</a> - Double bonds are susceptible to oxidative damage (unlike saturated fats).<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=734">12:14</a> - The double bonds can be attacked by oxygen or catalysts like iron.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=746">12:26</a> - LA per se is harmless, but it’s breakdown products are highly toxic.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=780">13:00</a> - e.g. COVID19 kills you by inducing ARDS (advanced respiratory distress syndrome)<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=790">13:10</a> - Higher LA in your body makes you more susceptible to ARDS.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=798">13:18</a> - The progression of ARDS is measured by the build up of metabolites of LA e.g. HNE and leukotoxin.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=815">13:35</a> - LA metabolites are an epidemiological study confounder because...<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=826">13:46</a> - ...e.g. in ARDS a decrease of LA is not a sign of health, it’s a sign of toxic metabolite buildup that kills the patient.<br><br>(2b) - LA causes disease by disrupting mitochondrial electron transport.<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=854">14:14</a> - LA changes the FAD2:NADH ratio causing a defect in the adipocyte signalling system determining if it’s full or not.<br><br>For more info on this see Paul’s videos with Peter Dobromylskyj &amp; Brad Marshall as this video is primarily concerned with metabolites of LA.<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=892">14:52</a> - SUMMARY - There are at least two potential mechanisms by which LA causes disease.<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=903">15:03</a> - Diagram showing breakdown products of LA by enzymes or free radicals into: 9-HpODE &amp; 13HpODE<br>- Glutathione Peroxidase further creates: 9-HODE &amp; 13-HODE<br>- Hydroxy FA Dehydrogenase further creates: 9-oxoHODE &amp; 13-oxoHODE<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=930">15:30</a> - Subset of the problem is therefore: <br>LA present ancestrally in small amounts but is now present in large amounts. &nbsp;It’s unstable and breakdown products are harmful to humans.<br><br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=988">16:28</a> - The affects of LA on Cardiolipin is an additional problem.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1002">16:42</a> - Cardiolipin is a mitochondrial organelle made of 4-fatty-acids [attached to a phospholipid] uniquely found in mitochondria, bacterial and chloroplasts in plants.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1011">16:51</a> - Cardiolipin is what allows the electron transport chain to function.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1018">16:58</a> - It’s what moves protons along and moves electrons back.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1023">17:03</a> - It holds the mitochondria together and gives them their shape.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1030">17:10</a> - The mitochondrial complexes for electron transport are bound into cardiolipin forming super complexes.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1039">17:19</a> - &nbsp;If cardiolipin is damaged or removed, then the whole mitochondria stops working [it’s the kill switch for apoptosis/cell-death].<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1050">17:30</a> - Cardiolipin FA composition is determined by diet &amp; DNA.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1069">17:49</a> - Crucially, increasing dietary LA changes cardiolipin composition in many tissues towards a more omega-6 FA composition,<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1087">18:07</a> - and Omega-6 FAs make cardiolipin more susceptible to oxidation damage.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1095">18:15</a> - once oxidised cardiolipin stops electron chain function.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1115">18:35</a> - <br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1123">18:43</a> - NOTE: cardiolipin only oxidises when its comprised of LA.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1130">18:50</a> - Therefore Tucker believes this is the fundamental mechanism behind mitochondrial dysfunction and thus metabolic dysfunction and chronic diseases.<br><a href="https://www.youtube.com/watch?v=DyVwn0kRGJs&amp;t=1142">19:02</a> - Mitochondrial dysfunction is present in every metabolic disease and likely causal by this mechanism.

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• HU

  @huanjie1628 · 5 years ago

  Rumour has it he still hasn&apos;t made that cup of tea yet.

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• MI

  @microcolonel · 5 years ago (edited)

  After not consuming high PUFA oils and changing almost nothing else, I find that my ability to process carbohydrates without weird satiety and energy effects is greatly improved.<br><br>It is also really really hard to overconsume fruits like grapes and apples, for me. If I eat an apple now I feel done with fruit for about four hours.<br><br>I enjoy fruit a lot, and I find it helpful when programming; I also like consuming it before going on a long walk which should be 3-4x or more the caloric load as the fruit, I find this keeps my mind working the whole time.

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• RI

  @RickCartwright · 5 years ago

  This was one of the best yet in the series on Seed Oils. Excellent.

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• TN

  @tnicole902 · 5 years ago

  I love Tucker&apos;s info but we should crowdfund a decent mic for him. Almost every interview I&apos;ve seen with him as an annoying sound issue.

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• FE

  @Femmefitchic · 5 years ago (edited)

  After going low-carb, Paleo, then Keto (from 2011 to May 2021) and still having lingering metabolic issues over those years, THIS!!!!!!!!…”seed oil toxicity” was the final piece of the puzzle for me to fix my deathly metabolic ills. I was consistently still taking in large amount of LA during extensive travels on cruise ships and restaurants 3/4th of each year; nutrient dense low-carb selections from menus were prepared with seed oils😣🤨. A MILLION THANKS for this!!!

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• RN

  @rndst6 · 5 years ago

  Paul!!! Adress olive oil specifically please!!!

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• AR

  @AriesGirlHagitude · 4 years ago

  Very interesting, however unfortunate the constant sound of a tea kettle in the background. Likely not a tea kettle, but that’s exactly what it sounded like. 🧐

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• LE

  @leannebahuaudbradley569 · 5 years ago

  I’m absolutely living your deep dive into PUFAs. And the study on non alcoholic fatty liver is so interesting! Thanks you!

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• AN

  @andreaskarlsson6352 · 4 years ago

  Give these men the Nobel prize

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